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What does ZFHO stand for?

ZFHO stands for zona-free hamster oocyte


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Data indicate that sperm-oocyte fusion is initiated by signal transduction processes that involve adhesion molecules on both sperm and oocyte plasma membranes that belong to the family of integrins. 40, 41, 42 Integrins are a class of heterodimeric adhesion receptor molecules that participate in cell-to-cell and cell-to-substratum interactions, and they are present on essentially all human cells. Integrins that recognize the Arg-Gly-Asp sequence (RGD) have been detected on the plasma membrane of oocytes. Fibronectin and vitronectin are glycoproteins that contain functional RGD sequences, and they are present on spermatozoa. 40, 41, 42, 43 When oligopeptides specifically designed to block fibronectin or vitronectin receptors were tested on human spermatozoa in a zona-free hamster oocyte.