The neural cell adhesion molecule (NCAM) is involved in the development and synaptic plasticity of the brain. Differential splicing of the variable alternative spliced exon (VASE) in the fourth immunoglobulin domain can dramatically change the functional properties of NCAM. This paper discusses our analysis of the levels of different expression of VASE-containing NCAM (NCAM-VASE+) and VASE-lacking NCAM (NCAM-VASE−) mRNAs in the dorsal and ventral hippocampus of senescence-accelerated mice (SAM).