This definition appears rarely
Although combination therapy is recommended by some experts for treatment of deep-seated infections such as prosthetic valve endocarditis (272), there are no controlled trials demonstrating the superiority of the combination over vancomycin alone. Combination of vancomycin and gentamicin was reported to be more nephrotoxic than gentamicin alone (123,125). Three studies failed to show better cure rates with combination therapy than with single-drug therapy for S. aureus endocarditis when the total length of therapy was 4 to 6 weeks (1, 211,432). Definitive guidelines for the use of vancomycin-gentamicin combination.