What does U-ARF stand for?
U-ARF stands for uranyl nitrate-induced acute renal failure
This definition appears rarely
Samples in periodicals archive:
Effects of dietary protein on uranyl-nitrate-induced acute renal failure. Andrews PM, Bates SB.
Uranyl nitrate-induced acute renal failure in the rat: Micropuncture and renal hemodynamic studies. Rats were studied after uranyl nitrate administration to define the mechanism(s) responsible for acute renal failure (ARF). Early (six hours) in the course of ARF, proportional decreases occurred in renal blood flow rate (RBF) and whole kidney and single nephron glomerular filtration rates (GFR), to 64%, 67% and 69% of control values, respectively.
It has been reported that the total body clearance (CL) renal clearance (CLR) and/or nonrenal clearance (CLNR) of drugs which were eliminated mainly by metabolism and by excretion were altered in rats with uranyl nitrate-induced acute renal failure (U-ARF rats). The drugs eliminated mainly by metabolism include propranolol (22), theophylline (12), amiodarone (8), diltiazem (19), azosemide (21), DA-125, a new anthracycline (17), and adriamycin (18).
In uranyl nitrate (UN)-induced acute renal failure (ARF) glomerular ultrafiltration coefficient (Kf) decreases because of unknown reasons. Since transport of water across the glomerular capillary wall occurs predominantly extracellularly through the endothelial fenestrae (EF), a reduction in the diameter and/or the density of EF can reduce the extracellular filtration area and the glomerular Kf. To examine this possibility, ARF was induced in rats by intravenous administration of UN in low (15 mg/kg) and high doses (25 mg/kg).