What does E2 stand for?
E2 stands for ubiquitin carrier protein
This definition appears rarely
See other definitions of E2
Samples in periodicals archive:
This process turned out to be similar to that of peptide bond formation that is catalyzed by tRNA synthetase following amino-acid activation during protein synthesis or during the nonribosomal synthesis of short peptides. 57 Using the unravelled mechanism of ubiquitin activation and immobilized ubiquitin as a 'covalent' affinity bait, the three enzymes that are involved in the cascade reaction of ubiquitin conjugation were purified by Ciechanover, Hershko, and their co-workers. These enzymes are: (i) E1, the ubiquitin-activating enzyme; (ii) E2, the ubiquitin-carrier protein.
The first, identified as E1 (also called ubiquitin-activating enzymes), activates ubiquitin in an ATP-dependent manner such that the ubiquitin is bound to the E1 enzyme via a high-energy thiol ester. The next class of enzyme, referred to as E2 (also called ubiquitin-conjugating enzymes or ubiquitin-carrier proteins.
Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the activation component E1; the activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein.