This definition appears rarely
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The liver is permanently exposed to food-derived dietary and microbial antigens from the gastro-intestinal tract, as well as antigens from apoptotic tumour cells, thus leading to liver being an inherent tolerogenic microenvironment (154). Local immune therapy is an interesting option for the treatment of HCC or liver metastases. Promising results on survival have been reported in patients with liver metastases from primary uveal melanoma after immunoembolization with granulocyte-macrophage colony-stimulating factor (GM-CSF) mixed with Lipiodol® (associated with Gelfoam®) and administered into the hepatic artery (155). Local administration of dendritic cells (DCs) stimulated with OK432, a streptococcus-derived anti-cancer immunotherapeutic agent, in the presence of interleukin (IL)-4 and GM-CSF, during TACE procedure in HCC patients has been found to be safe and prolonged recurrence-free survival of patients compared with the historical controls treated with transcatheter hepatic arterial embolization.