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Target definition of moving lung tumors in positron emission tomography: correlation of optimal activity concentration thresholds with object size, motion extent, and source-to-background ratio. Med Phys 37(4):1742-52, 4/2010. PMCID: PMC3820629.
35. Daisne JF, Sibomana M, Bol A, Doumont T, Lonneux M, Gregoire V. Tri-dimensional automatic segmentation of PET volumes based on measured source-to-background ratios: influence of reconstruction algorithms. Radiother Oncol. 2003;69:247–250. doi: 10. 1016/S0167-8140(03)00270-6.
In addition to the fixed thresholding-based techniques, there are other adaptive thresholding-based approaches that incorporate tumor volume, background activity, and source-to-background ratios [278–283]. Nestle et al.  compared different GTVs obtained from different methods to look for the optimal threshold value. Four different GTVs are obtained using four different methods: (1) GTVvis obtained by visual interpretation, (2) GTV40 obtained by applying a threshold of 40% of the SUVmax, (3) GTV2.