Impact of lithium on efficacy of radioactive iodine therapy for Graves' disease: a cohort study on cure rate, time to cure, and frequency of increased serum thyroxine after antithyroid drug withdrawal. Bogazzi F1, Giovannetti C, Fessehatsion R, Tanda ML, Campomori A, Compri E, Rossi G, Ceccarelli C, Vitti P, Pinchera A, Bartalena L, Martino E.
In general, serum thyroxine normalizes before serum TSH, and both may normalize before the disappearance of all of the symptoms of hypothyroidism. In the severely hypothyroid patient with long-standing disease, a number of profound alterations may occur as the hypothyroid state is corrected. Thus, loss of weight, primarily due to mobilization of interstitial fluid as the glycosaminoglycans are degraded, is prominent.