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The "self-administration" behavioral paradigm serves as an animal behavioral model of the human pathology of addiction. During the task, animal subjects are operant conditioned to perform one action, typically a lever press, in order to receive a drug. Reinforcement (through the use of the drug) occurs contingent upon the subject performing the desired behavior. Drug dosing in self-administration studies is response-dependent.
Bupropion-varenicline interactions and nicotine self-administration behavior in rats. Hall BJ1, Slade S1, Wells C1, Rose JE1, Levin ED2.