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What does R:S stand for?

R:S stands for replacement-to-silent

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This definition appears rarely

Samples in periodicals archive:

ANA: anti-nuclear antibody; APC: antigen-presenting cell; APRIL: a proliferation-inducing ligand; BAFF: B cell-activating factor; BCR: B-cell receptor; BLyS: B lymphocyte stimulator; CDR: complementarity-determining region; DC: dendritic cell; dsDNA: double-stranded DNA; FDC: follicular dendritic cell; FR: framework region; GC: germinal center; ICOS: inducible T-cell co-stimulator; Ig: immunoglobulin; IL: interleukin; MHC: major histocompatibility complex; NF-?B: nuclear factor-kappa-B; R/S: replacement-to-silent.
Scientists performed experiments on the opossums and found that there were multiple trials that showed replacement to silent substitutions in the von Willebrand Factor (vWF) gene which encodes for a venom-targeted hemostatic blood protein. These substitutions are thought to weaken the connection between vWF and a toxic snake venom ligand (botrocetin) which changes the net charge and hydrophobicity.