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How to control leg swelling in someone with polycystic kidney disease (PKD)? With PKD, an alteration of the renin-angiotension-aldosterone system can cause us to retain sodium. It is possible for this to result in noticeable leg, ankle and.
Use caution in treating patients whose renal function may depend on the renin-angiotension-aldosterone system.
The renin–angiotension–aldosterone system, acting in concert with vasopressin and atrial natriuretic hormone,39 regulates fluid and electrolyte balance within narrow limits. A fall in effective blood volume decreases renal perfusion, which affects angiotensin I, the majority of which is converted in one passage through the lung to angiotensin II. Angiotensin II constricts vascular smooth muscle and promotes aldosterone secretion from the adrenal gland by stimulating 20,22-desmolase and the conversion of corticosterone to aldosterone.