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A variety of chemokines and chemokine receptors have been detected in neoplastic tissues [1, 4]. We will focus our attention primarily on the C-C chemokine ligand 5 (CCL5), also known as Regulated upon Activation, Normal T-cell Expressed, and Secreted.
Chemokines: chemerin, monocyte chemotactic protein-1 (MCP-1), macrophage inhibitory protein-1 alpha (MIP-1α), regulated upon activation, normally T cell expressed and secreted.
Decreases from baseline in the NF-kB controlled pro-inflammatory chemokines IL-8, ''regulated upon activation, normal T cell expressed and secreted.
At both the mRNA and protein levels of expression, ICAM-1 ligation was found to upregulate ICAM-1’s own expression in a positive-feedback loop. In addition, the expression of RANTES mRNA and protein was also found to be upregulated by ICAM-1 ligation. RANTES, or Regulated upon Activation Normal T-cell Expressed and Secreted.
The proinflammatory nature of cisplatin-induced AKI has been well documented . Secretion of various cytokines such as IL-1-beta, IL-6, IL-18, monocyte chemotactic protein-1 (MCP-1), regulated upon activation normal T cell expressed and secreted.