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What does RME stand for?

RME stands for rat mammary epithelial


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Maintaining the correct polarized morphology of the lactiferous duct tree requires another essential component – mammary epithelial cells extracellular matrix (ECM) which, together with adipocytes, fibroblast, inflammatory cells, and others, constitute mammary stroma. [4] Mammary epithelial ECM mainly contains myoepithelial basement membrane and the connective tissue. They not only help to support mammary basic structure, but also serve as a communicating bridge between mammary epithelia and their local and global environment throughout this organ's development.
Based on the evidence, we asked whether NOTCH2 mediates miR-205–regulated EMT and stem cell properties. We found that KD of NOTCH2 to block the activation of NOTCH2 in miR-205 KD cells could significantly reduce the CD24–CD44+ cell population enhanced by loss of miR-205 (Figure 3, A and B). Similarly, in the aggressive breast cancer cell lines BT-549, MDA-MB-231, and PT, which exhibit repressed endogenous miR-205 expression and an enriched CD24–CD44+ cell population, reexpression of miR-205 resulted in a significantly reduced CD24–CD44+ cell population (Figure 3C), diminished sphere formation, and decreased ZEB1 expression; it also abolished mammary xenograft tumor formation in immunodeficient mice (Figure 3C, Supplemental Figure 3, A–D, and Table 2). The enhancement of the EMT and stemness phenotype caused by miR-205 suppression could be reversed by KD of NOTCH2 as well as by treatment of a ?-secretase inhibitor (GSI) (Figure 3, D and E, and Supplemental Figure 3, E and F). Together, these data suggest that NOTCH2 is a critical target that mediates miR-205–regulated stem cell properties in mammary epithelial.
Recent evidence suggests that cells that undergo EMT gain stem cell-like properties, thus giving rise to Cancer Stem Cells (CSCs). Upon transfection by activated Ras, the subpopulation of CD44high/CD24low immortalized human mammary epithelial cells as well as cancer cells that possess stem-like properties increases with the concomitant induction of EMT. [30] Also, ZEB1 is capable of conferring stem cell-like properties, thus strengthening the relationship between EMT and stemness.