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See also: www. cellapplications. com/primary-cells/h uman-umbilical-vein-endothelial-cells-hu vecEndothelial cells line the blood vessels of the entire circulatory system, from the aorta to capillaries, and act as the barrier between circulating blood and the rest of the vessel wall. At the cellular interface, endothelial cells are involved in the processes of angiogenesis, vasculogenesis, vasoregulation, coagulation, fibrinolysis, and blood cell trafficking. Cell Applications' human endothelial cells include* Pulmonary artery endothelial cells.
Here we describe a microRNA (miRNA)-dependent association between apelin (APLN) and fibroblast growth factor 2 (FGF2) signaling in pulmonary artery endothelial cells (PAECs). APLN deficiency in these cells led to increased expression of FGF2 and its receptor FGFR1 as a consequence of decreased expression of miR-424 and miR-503, which directly target FGF2 and FGFR1. miR-424 and miR-503 were downregulated in PAH, exerted antiproliferative effects in PAECs and inhibited the capacity of PAEC-conditioned medium to induce the proliferation of pulmonary artery smooth-muscle cells.
Cryopreserved Clonetics™ Human Pulmonary Artery Endothelial cells are guaranteed through 15 population doublings and test negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis is provided for each cell lot purchased.