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What does P4HI stand for?

P4HI stands for prolyl 4-hydroxylase inhibitor


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Are hypoxia-inducible factor prolyl hydroxylase inhibitors useful for stimulating stroke recovery in addition to their putative effects on neuroprotection? At the cellular and molecular level, neural plasticity in response to injury may be enhanced by a number of established biological manipulations that overcome intrinsic and environmental barriers to repair (Ratan and Noble, 2009). A particularly promising approach is the recognized ability of newly born neurons in the subventricular zone to deviate from their normal migration pathway, toward regions of damage (.
Hypoxia inducible factor-a (HIF-alpha) is a transcription factor that acts as the body's main sensor to low oxygen tension, and HIF responds to anemia (i. e. hypoxia) to increase erythropoiesis by elevating transcription of EPO and iron processing genes. HIF-alpha function is regulated by a family of conserved HIF prolyl hydroxylases (HIF-PH), which hydroxylate HIF-alpha and induce its degradation under normoxic conditions, but which are inhibited under hypoxia leading to HIF-alpha stabilization and activation. We developed a novel series of HIF prolyl hydroxylase inhibitors.