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What does PAC3 stand for?

PAC3 stands for platelet-associated IgG , C3

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PAMELOR® PANCREATIC ELASTASE 1 PANCREATIC POLYPEPTIDE PANORAMA PRENATAL TEST PARAINFLUENZA PCR PARAINFLUENZA VIRUS CULTURE PARANEOPLASTIC AUTOANTIBODY EVALUATION, SERUM PARANEOPLASTIC EVALUATION, CSF PARASITE, IDENTIFICATION PARASITES PARATHYROID HORMONE, INTACT PARIETAL CELL ANTIBODY PAROXETINE (PAXIL®) PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PARVOVIRUS B19 DNA (PCR) PARVOVIRUS B19 IgG ANTIBODY PARVOVIRUS B19 IgG, IgM ANTIBODY PARVOVIRUS B19 IgM ANTIBODY PCNA ANTIBODIES PCP PEMPHIGUS SEROLOGY PENTOBARBITAL (NEMBUTAL®) PERPHENAZINE (TRILAFON®) PERTUSSIS (BORDETELLA) CULTURE PERTUSSIS PCR PANEL pH, FECAL PHENCYCLIDINE, SERUM, QUALITATIVE PHENCYCLIDINE, URINE CLINICAL GC/MS CONFIRMATION (QUANTITATIVE) PHENCYCLIDINE, URINE, CLINICAL, QUALITATIVE PHENCYCLIDINE, URINE, FORENSIC SCREEN PHENCYCLIDINE, URINE, FORENSIC, GC/MS CONFIRMATION (QUANTITATIVE) PHENOBARBITAL PHENYLALANINE MONITORING, PLASMA PHENYTOIN (DILANTIN®) PHENYTOIN, FREE (DILANTIN®, FREE) PHOSPHATIDYL SERINE IgG, IgM, IgA ANTIBODIES PHOSPHOLIPIDS, SERUM OR PLASMA PI-LINKED ANTIGEN, BLOOD PLAC TEST PLASMA HEMOGLOBIN PLASMA RENIN ACTIVITY PLASMINOGEN ACTIVATOR INHIBITOR GENOTYPE 4G/5G PLASMINOGEN ACTIVATOR INHIBITOR, ACTIVITY PLASMINOGEN ACTIVITY, PLASMA PLATELET ANTIBODIES PLATELET ANTIBODY (INDIRECT) PLATELET ASSOCIATED.
This assay substantiated that the majority of patients with idiopathic thrombocytopenic purpura have increased levels of IgG on their platelets. Platelet-associated C3 was elevated in a subset of these patients, some of whom had normal levels oet-associated IgG, thus suggesting a role for C3 in the pathogenesis of the thrombocytopenia. The assay enabled us to anticipate a change in clinical status, establish the presence of immunologic remission after splenectomy and propose several mechanisms by which corticosteroids act.
Platelet-associated C3, as detected by Western blot analysis using polyclonal anti-C3c Abs (A, B) or anti-C3a mAb 7SD17. 3 (C). A, Platelets were activated by TRAP in PRP for 0, 15, or 30 min. Lanes 1-3 show membrane-bound C3 at the three time points, and lanes 4–6 show control C3, C3b, and iC3b, respectively, at 3 µg each. B, Binding and cleavage of purified C3 after incubation with washed, activated platelets in the absence (lane 1) or presence of factor I (lane 2) or with both factor I and factor H (lane 3).
Low or normal platelet-associated PF4 levels result in low expression of HIT antigens on platelet surfaces, with resulting low potential for platelet activation in presence of HIT antibodies. In contrast, high platelet-associated PF4 levels lead to increased expression of HIT antigens on platelet surfaces, predisposing to greater HIT antibody-induced platelet activation and hence greater risk of HIT.
Harbert J. et al. Inhibitory effects of fish oil on platelet-associated thrombin generation as measured by the calibrated automated thrombogram: an in vitro study. Int Soc Thromb Hemost 2014; (abstract 604).