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However, the effect of dietary exposure to phytoestrogens on LH secretion seemed to be dependent on the type of phytoestrogen and reproductive status and seasonality. In ovariectomized ewes, an increased concentration of coumestrol in the diet significantly reduced the amplitude of LH pulses during the breeding, but not during the anestrous season . Furthermore, Romanowicz et al.  investigated whether genistein was capable of evoking effective changes in LH and prolactin (PRL) secretion in ovariectomized ewes during seasonal anoestrus. After several hours of genistein infusion into the third ventricle, plasma LH concentrations.
Substantially lower antepartum indinavir plasma concentrations.
Upon multiple dosing of fenofibrate, fenofibric acid steady state is achieved within 9 days. Plasma concentrations of fenofibric acid at steady state are approximately double those following a single dose. Serum protein binding was approximately 99% in normal and hyperlipidemic subjects.