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La phospholipase Cß est une enzyme transmembranaire. À la suite de son activation par un récepteur couplé aux protéines G, l’hydrolyse du PIP2 membranaire provoque une augmentation de la concentration intracellulaire du second messager IP3. La fixation d'IP3 sur ses récepteurs induit l’activation des canaux calciques des citernes du réticulum endoplasmique, provoquant la sortie du calcium de ces réserves et donc une augmentation de la concentration cytosolique des ions Ca2+.
Biological Activity Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6. 4 μM); antiviral and antitumor agent. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.
Muto et al (1997) The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J. Pharmacol. Exp. Ther. 282 1379.
Replacement of the myristoylation signal of MA in HIV-1 with a plasma membrane targeting motif (N-terminal 120 amino acids) of the phospholipase.
It is possible that the exposure of cholesterol at the membrane surface might be facilitated by other membrane-damaging toxins secreted such as phospholipase C, which cleave the head groups of phospholipids increasing the exposure of cholesterol. Two organisms, Clostridium perfringens that produces perfringolysin O (CDC) and a-toxin during clostridial myonecrosis.  and listeriolysin O (CDC) and phospholipases C, which are released by Listeria monocytogenes leading to the virulence of these bacteria.
EtNP-6Mana1-2Mana1-6Mana1-4GlcNa1-6myoinositol), are highly conserved between protozoa and mammals. In contrast, the side chains (shown as X, Y, and Z) that are attached to the mannose residues in the glycan backbone are highly variable and can contain a variety of other sugars and additional ethanolamine phosphate groups. The hydrophobic part of the phosphatidylinositol (which will be embedded in the lipid bilayer) is shown as a 1-alkyl, 2-acyl structure, although 1,2-diacylglycerol, 1-alkylglycerol, or ceramide are also found. The hydrocarbon chain length and degree of unsaturation are also highly variable among proteins (the example shown here is for human folate-binding protein). The inositol ring can also become acylated (not shown), which makes the GPI anchor insensitive to degradation by PI-phospholipase.
This explanation may also hold for scarab beetles and for detritus-feeding nematoceran Diptera larvae that usually feed on refractory materials such as humus. Nevertheless, mechanisms other than high gut pH must account for the resistance to tannin displayed by some locusts (Bernays et al. , 1981) and beetles (Fox and Macauley, 1977). One possibility is the effect of surfactants such as lysolecithin, which is formed in insect fluids due to the action of phospholipase.
Three α1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: α1A (chromosome 8), α1B (chromosome 5), and α1D (chromosome 20). Terazosin is the first α1-receptor antagonist to demonstrate selectivity for the α1A-receptor. All three receptor subtypes appear to be involved in maintaining vascular tone. The α1A-receptor maintains basal vascular tone while the α1B-receptor mediates the vasocontrictory effects of exogenous α1-agonists. Activation of α1-receptors activates Gq-proteins, which results in intracellular stimulation of phospholipases.