This definition appears rarely
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Well-organized fibrous tissue surrounds the cyst. Papillary projections extend from the secretory layer into the cyst cavity, depicting decapitation secretion. The secretory cells contain periodic acid-Schiff–positive, diastase-resistant granules and occasionally contain pigment granules, which provide the brown color of the cystic fluid. This pigment is neither melanin nor hemosiderin. On electron microscopy, secretory cells have numerous, dense, lysosomal-type secretory granules typical of apocrine gland cells.
Mucus producing cells are found in some cases. The clear cells contain glycogen and periodic acid-Schiff-positive, diastase-resistant.
 CEA and EMA highlight the ducts and the intracytoplasmic lumina of porocarcinoma and hidradenocarcinoma. , Primary mucinous carcinoma of the skin can be mistaken histologically for a metastasis from extracutaneous sites, particularly the breast, or the gastrointestinal tract. Primary mucinous carcinoma of the skin is positive for cytokeratin 7, S100 protein, estrogen, and progesterone receptors, while negative for CK20.  Primary cutaneous mucinous carcinomas often have an area of carcinoma in situ, in which there are actin-positive myoepithelial cells at the edges of some of the aggregates.  The most reliable histopathologic criteria for identifying apocrine skin carcinoma are decapitation secretion, periodic acid-Schiff-positive diastase-resistant.
A single report of 2 cutaneous examples has recently appeared in the dermatopathology literature. 42 The initial pathologic impression was that the lesion represented an unusual histiocytic reaction, which was reinforced by the presence of a prominent lymphocytic infiltrate. The constituent cells were polygonal or polyhedral and had a distinctive eosinophilic granular cytoplasm that differed from the classically glassy cytoplasm of epithelioid histiocytes and epithelioid melanoma cells. Their nuclei were generally small and centrally located and displayed punctate nucleoli. The granules were sometimes conglutinated and were lightly positive on Masson trichrome staining but exhibited vivid periodic acid–Schiff–positive, diastase-resistant.
Liver biopsy is indicated to confirm the characteristic histologic findings of α1-antitrypsin deficiency with periodic acid-Schiff positive, diastase-resistant globules in periportal hepatocytes [Banda, 1988], [Sharp, 1976] and also to document severity of disease. Treatment is supportive and liver transplantation is curative [Vennarecci, 1996]. Data regarding the risk of hepatocellular carcinoma in this disease is confounded by coinfection with hepatitis B and C in many of the patients.