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p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge.
Results of these experiments, published in Molecular Cell, show that p53-activated genes and p53-repressed genes are two functionally separable transcriptional units during ES cell differentiation and somatic cell reprogramming. Li and Huang’s experimental model make it possible to discover the separate molecular activities that underlie p53’s dual roles in response to genomic damage. Once these roles are better understood by studying a genome-wide picture of p53 signaling in ES/iPS cells, the research team will be able to address the link to tumorigenesis.