This definition appears rarely
4 Mb), a region of homology with human Chromosomes 8q11-13 and 6q12. The phenotype of col/col mice is obvious a few days after birth and includes retardation in post-natal development and partial alopecia. Histologically, the skin shows altered hair follicle cycle at several time points. No other histological lesions were observed. Furthermore, tumor multiplicity after chemical skin carcinogenesis is higher in mutant mice than wild-type littermates.