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Drugs are transferred from the plasma into the bile through the hepatocytes. This transport is due to active secretion of drugs into the bile by means of transport systems: e. g. the organic anion transporting polypeptides (OATPs), the P-glycoprotein transport system and the multidrug resistance-associated proteins (Mrps). The latter are important for the excretion of conjugated metabolites.
Varma, K. Sandy Pang,et al. Pharmacokinetic changes of drugs in a rat model of liver cirrhosis induced by dimethylnitrosamine, alone and in combination with diabetes mellitus induced by streptozotocin Unji Lee and Euichaul OhCholine transporter-like proteins CTLs/SLC44 family as a novel molecular target for cancer therapy Masato InazuEmerging roles of metal solute carriers in cancer mechanisms and treatment Nancy N. Jong and Mark J. McKeagePutative roles of organic anion transporting polypeptides.
We have previously identified the cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in several human colon and lung cancer tissues. Ct-OATP1B3 is a variant of the liver-type OATP1B3 (Lt-OATP1B3) mRNA, which is a hepatocyte plasma membrane transporter with broad substrate specificity. However, in cancer tissues, both the detailed characteristics of Ct-OATP1B3 mRNA expression and its biological functions remain unclear.
An exception occurs with SLC family 21 (the organic anion transporting polypeptide.
75 - B. Hsiang, Y. Zhu, Z. Wang, Y. Wu, V. Sasseville, W. P. Yang, T. G. Kirchgessner, 1999 A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem, 274 52 37161 37168.