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Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes. Wang J1, Bushman J, Wang X, Mayer-Proschel M, Johnson M, Noble M.
The oligodendrocyte/type-2 astrocyte lineage (1990) by W RICHARDSON, M RAFF, M NOBLE.
To directly examine this question, we expressed identical oncogenes in two types of glial progenitor cells, glial-restricted precursor (GRP) cells and oligodendrocyte/type-2 astrocyte progenitor cells (O-2A/OPCs), and in astrocytes of the mouse CNS (either directly purified or generated from GRP cells). In vitro, expression of identical oncogenes in these cells generated populations differing in expression of antigens thought to identify tumor initiating cells, generation of 3D aggregates when grown as adherent cultures, and sensitivity to the chemotherapeutic agent BCNU.
In the rat optic nerve there are two distinct types of astrocyte1: type-1 astrocytes develop from one type of precursor cell2, and type-2 astrocytes develop from bipotential, oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells3, that initially give rise to oligodendrocytes (which make myelin in the CNS), and then to type-2 astrocytes4. Type-1 astrocytes form the glial limiting membrane at the periphery of the optic nerve5 and are probably responsible for glial scar formation following nerve transection6.
Abstract. We have been studying the differing characteristics of oligodendrocyte-type-2 astrocyte (O-2A) progenitors isolated from optic nerves of perinatal and adult rats. These two cell types display striking differences in their in vitro phenotypes. In addition, the O-2Aari-al progenitor population appears to have a limited lifespan in vivo, while 0-2Aadull progenitors appear to be maintained throughout life.