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What does SLE stand for?

SLE stands for non-systemic lupus erythematosus

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The induction of a Guillain-Barre syndrome in rabbits after immunization with a peptide derived from Campylobacter jejuni is explained by mimicry between C. jejuni antigens and peripheral nerve axonal antigens. Other models involve chemical modification of autoantigens, as in the case of iodine-induced autoimmune thyroiditis. These mechanisms have so far only limited clinical counterparts (rheumatic fever, Guillain-Barre syndrome and drug-induced lupus or myasthenia gravis) but one may assume that unknown viruses may be at the origin of a number of chronic autoimmune diseases, such as type I diabetes and multiple sclerosis) as illustrated by the convergent data incriminating IFN-alpha. in the pathophysiology of type I diabetes and systemic lupus erythematosus.
Several techniques are used to detect ANAs. Clinically the most widely used method is indirect immunofluorescence (IF). The pattern of fluorescence suggests the type of antibody present in the people's serum. Direct immunofluorescence can detect deposits of immunoglobulins and complement proteins in the people's skin. When skin not exposed to the sun is tested, a positive direct IF (the so-called lupus band test) is an evidence of systemic lupus erythematosus.
Systemic lupus erythematosus The classic example of a multi-systemic autoimmune disease is systemic lupus erythematosus (SLE), commonly referred to as lupus. Lupus is often called the "great imitator" because it can mimic almost any other disease state. The signs of SLE may be acute (sudden onset) or chronic and usually they wax and wane. A fluctuating fever that does not respond to antibiotics is one of the classic clinical signs of SLE.
Rahman A, Isenberg DA, Systemic lupus erythematosus, in N. Engl. J. Med. , vol.  358, nº 9, febbraio 2008, pp.
Vaarala O, Alfthan G, Jauhiainen M, Aho K, Palosuo T: Crossreaction between antibodies to oksidized low-density lipoprotein and to cardiolipin in systemic lupus erythematosus. Lancet 1993, 341:923-5. PubMed Abstract | Publisher Full Text.