This definition appears rarely
1999; Kaibuchi et al. , 1999; Nagumo et al. , 2000; Somlyo and Somlyo, 2000; Sward et al. , 2000) indicate that in smooth muscle a Rho-regulated system of MLCP exists. Rho-kinase is the major player in this system, the enzyme phosphorylates the 130-kDa myosin binding subunit of MLCP and thereby inhibits MLCP activity. Due to the antagonism between MLCK and MLCP, inhibition of MLCP results in an increase in the phosphoryl content of LC with concomitant increase in muscle force.