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What does M-CFC stand for?

M-CFC stands for monocyte-macrophage colony-forming cell


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An in vitro monocyte-macrophage colony-forming cell (M-CFC) has been detected in canine bone marrow (BM). The colonies derived from these progenitor cells were similar to murine-derived M-CFC (MacVittie and Porvaznik, 1978, J. Cell Physiol. 97:305-314) colonies, since they showed a singular macrophage line of differentiation, a lag of 14-16 days before initiating colony formation, and they survived significantly longer in culture in the absence of colony-stimulating factor (CSF) than granulocyte-macrophage colony-forming cells (GM-CFC).
Recently, several subpopulations or different classes of colony-forming cells have been described (5, 13, 14, 16, 32). Lin and coworkers (5, 12–15) have reported on a class of monocyte-macrophage colony-forming cell (CFC) derived from thioglycollateinduced peritoneal exudate (PE-CFC) and pleural effusion (PL-CFC) as well as from free alveolar cells. van den Engh and Bol (29) and Williams and van den Engh (32) have also reported the detection of an additional subpopulation(s) of bone marrow-derived CFU-c that responded in the presence of CSA to the addition of specific enhancing factors.
[Show abstract] [Hide abstract] ABSTRACT: In vitro monocyte-macrophage colony-forming cells (CFC) have been detected in the thymus (30/10(6) cells) and in the cervical (22/10(6)) and mesenteric (20/10(6)) lymph nodes (LN) of the mouse. Thymus and LN derived CFC differed from bone marrow derived CFU-c in several characteristics parameters: (1) sole specificity of PMUE to induce colony formation (CF), (2) apparent singular line of monocyte-macrophage differentiation, (3) a marked 6- to 10-day lag period prior to initiation of CF, and (4) significantly slower rates of appearance of colonies in culture after initiation of CF.