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Thus, the dopamine system would be a likely candidate to help control voluntary physical activity because this is a motivated and rewarding behavior that involves motor control. However, to this point, the majority of studies investigating physical activity in humans have treated changes in neurotransmitter systems, such as dopamine, as a dependent factor that responds to physical activity stimuli such as intensity or duration of exercise. States another way, most investigations treat dopaminergic changes as a consequence of physical activity. Similarly, work done in animals has for the most part employed research designs focusing on neurotransmitter systems and “locomotion” in relation to diseases such as Parkinson's disease. However, extensive recent evidence presented by Garland and colleagues [16, 121-124] with mice selectively bred for high.