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This frustrating situation led one researcher to comment "rheumatoid arthritis rarely kills the patient; corticosteroids often do". These problems lead this writer to observe that apitherapy has never killed anyone and has negligible side effects. Thus, what valid criticisms can be raised against apitherapy for rheumatoid arthritis and multiple sclerosis? The question arises: how does bee venom work? The answer is not clear, but we have some hints. Bee venom has anti-inflammatory effects, it might well "shock" the immune system which somehow might correct imbalances, it causes pain, and it might stimulate the nervous system which, in turn, can exert influence on the immune system. Bee venom possesses chemical components responsible for these activities: anti-inflammatory action - mast cell degranulating peptide.
PEPTIDE 401– (mast cell degranulating peptide or MCD) has been shown to be 100 times more potent and effective as an anti-inflammatory than hydrocortisone. This offers an alternative without side effects to cortisone, prednisone and other NSAID’s as well.