What does LAH stand for?
LAH stands for low-affinity heparin
This definition appears rarely
See other definitions of LAH
Samples in periodicals archive:
Heparin molecules range in molecular weight from 3,000 to 30,000 kDa with a mean of 15,000, which corresponds to approximately 45 saccharide units (Fig 2). 8-10 Only about one-third of the heparin molecules possess the unique pentasaccharide sequence and it is this fraction that is responsible for most of the anticoagulant effect of heparin. 8,11 Heparin chains that lack the pentasaccharide sequence have minimal anticoagulant activity when heparin is given in therapeutic concentrations. However, at concentrations higher than those usually administered clinically, heparin chains with or without the pentasaccharide sequence can catalyze thrombin inhibition by heparin cofactor II (HCII), a second plasma cofactor. 12 At even higher concentrations, low-affinity heparin.
Human monomeric endostatin is a globular protein containing two disulfide bonds: Cys162-302 and Cys264-294.  It folds tightly, has a zinc binding domain at the N-terminus of the protein, and has a high affinity for heparin through an 11 arginine basic patch.  Endostatin also binds all heparan sulfate proteoglycans with low affinity.  Oligomeric endostatin (trimer or dimer) binds mainly with laminin of the basal lamina.