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LAIR1, (Leukocyte-associated immunoglobulin-like receptor 1) is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self.
Human chromosome 19 also carries a large collection of genes encoding receptor proteins with immunoglobulin-like domains. Genes of the closely related leukocyte immunoglobulin-like receptors (LILRA and LILRB), the leukocyte-associated immunoglobulin-like receptors (LAIR) and the killer cell immunoglobulin receptors (KIR) are found together in the leukocyte cluster region (LCR) of 19q13. 4. The proteins encoded by these loci function as receptors for specific classes of antigens on the surface of various types of immune cells.