This definition appears rarely
During the present study, significant changes in vWF concentration following TKR surgery were evident, with an increase from baseline up to day 3 postoperative and similarly for THR surgery although not significant. A significant increase in sICAM-1 was also demonstrated from baseline (preoperative) up to day 5 postoperative following THR surgery, with a similar trend being observed following TKR surgery. Data obtained from this study suggest that there is an increased liberation of vWF from the storage organelles of the vascular endothelium following surgery, and that ICAM-1 may be up-regulated and is being shed into the blood. The up-regulation of ICAM-1 fits with the increased levels of CD11b expression by leukocytes, which may facilitate leukocyte-endothelial cell interactions.