What does l-AD stand for?
l-AD stands for late-onset Alzheimer's disease
This definition appears rarely
Samples in periodicals archive:
Although a rare form of Alzheimer's disease occurs before age 65 (early-onset Alzheimer's disease), the most common variety of Alzheimer's disease usually begins after age 65 (late-onset Alzheimer's disease). The most common gene associated with late-onset Alzheimer's disease is called apolipoprotein E (APOE).
Genetics appears to play a part in both early- and late-onset Alzheimer’s disease. In early-onset Alzheimer’s, most cases are caused by specific genetic mutations— permanent changes in genes that can be passed on from a parent to a child. This results in early-onset familial Alzheimer’s disease, or FAD.
Late-Onset Alzheimer's Disease Most people with Alzheimer's have the late-onset form of the disease, in which symptoms become apparent in the mid-60s and later. The causes of late-onset Alzheimer's are not yet completely understood, but they likely include a combination of genetic, environmental, and lifestyle factors that affect a person's risk for developing the disease.
Wilson RS, Barral S, Lee JH, et al. Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family Study. Journal of Alzheimer's Disease. 2011;23(2):249–55. doi:10. 3233/JAD-2010-101515.