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What does iii stand for?

iii stands for in inter-subunit interactions


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Nonnucleoside reverse transcriptase inhibitor (NNRTI) induced conformational changes in HIV-1 reverse transcriptase (RT). Recent studies have shown that NNRTI can modulate the inter-subunit interactions between the 66kDa and 51kDa polypeptides of RT. The molecular mechanisms by which this occurs, and the impact that this has on RT enzyme functioning is not known. In light of this, the specific aims of this project are to: (1) determine the mechanisms by which NNRTI modulate the inter-subunit interactions and intra-subunit conformational changes of HIV-1 RT; and (2) define the molecular interactions in the HIV-1 RT dimer interface and to evaluate the consequences of altering the intrinsic dimeric stability on enzymatic activity.
A. Austin, and J. M. Berger. (2012) The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage. J Mol Biol. Schmidt, B. H. , N. Osheroff, and J.
Walker, 1999, PDB file 1Q01). Display as backbone and color chain. Question: How many c subunits, are in the Fo c-ring? Visualize the aspartate residue near the middle of one transmembrane segment of each c subunit. An atomic resolution structure of the complete ATP Synthase , including F1 and Fo with peripheral as well as central stalks, has not yet been achieved. However partial or complete structures of individual protein constituents, mutational studies, and evidence for inter-subunit interactions.