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What does HAC stand for?

HAC stands for human articular chondrocytes


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Some research has verified with isotope-labeled monoclonal antibodies that chondrocyte phenotype remains may be due to the attachment mediated via integrin, including members of both the ß1 and ß3 subunit families. Then, chondrocytes showed significant attachment to fibronectin matrix Gla protein, osteopontin, bone sialoprotein II, vitronectin, and COLII and VI [36, 37], which suggests a link between matrix synthesis and integrin expression in chondrocytes. Chondrocytes express several members of the integrin family, including a5ß1, the primary chondrocyte receptor for fibronectin. The a5ß1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes.
Di Battista JA, Dore S, Morin N, He Y, Pelletier JP, Martel-Pelletier J: Prostaglandin E2 stimulates insulin-like growth factor binding protein-4 expression and synthesis in cultured human articular chondrocytes: possible mediation by Ca(++)-calmodulin regulated processes. J Cell Biochem 1997, 65:408-419. PubMed Abstract | Publisher Full Text.