What does H-NS stand for?
H-NS stands for histone-like nucleoid structuring protein
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This data publication presents data from cultures of the wild type bacterium Vibrio cholerae and its isogenic mutant containing a deletion of the gene encoding the histone-like nucleoid structuring protein (H-NS). The cultures of the wild type bacterium expressing H-NS were tagged with the FLAG epitope. The authors used Illumina HiSeq 2000 for differential RNA-seq and Chromatin Immunoprecipitation (ChIP) sequencing using anti-FLAG M2 monoclonal antibody.
They are like pearls on necklace. The bacterial SMC proteins (structural maintenance of chromosomes) act as molecular clamps. ?Each of the nucleoids contains highly compacted supercoiled DNA (60%), nucleoid proteins NAPs (different from histones), topoisomerases and transcriptional factors and mRNAs. ? These nucleoids are transcriptionally active. These regulatory NAPs are: Fis (factor for inversion stimulation), HU (histone-like protein), H-NS (histone-like nucleoid structuring protein.
Whereas some bacteria are restricted to specific niches and have limited abilities to survive changes in their environment, others, such as members of the Enterobacteriaceae, can withstand wide fluctuations in temperature. In addition to regulating cellular physiology, pathogenic bacteria use temperature as a cue for activating virulence gene expression. This work confirms that the nucleoid-associated protein H-NS (histone-like nucleoid structuring protein.
Ghosh A, Paul K, Chowdhury R. 2006. Role of the histone-like nucleoid structuring protein in colonization, motility, and bile-dependent repression of virulence gene expression in Vibrio cholerae. INFECTION AND IMMUNITY 74 (5): 3060-3064.
Seiji Tsuge of Kyoto Prefectural University explained the role of HrpG and HrpX (master regulators) in the regulation of Xoo hrp genes (which encode the T3SS and its secreted proteins). He identified additional regulators involved in controlling hrp expression, in particular, the role of Xoo homologs of Histone-like nucleoid structuring protein.