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TGF-ß2 was first described in human glioblastoma cells. It was found that TGF-ß2 is capable of suppressing interleukin-2-dependent growth of T lymphocytes. Thereby, it was named glioblastoma-derived T cell suppressor factor (G-TsF). Physiologically, TGF-ß2 is expressed by neurons and astroglial cells in embryonic nervous system . It is also important in tumor growth enhancing cell proliferation in an autocrine way and/or reducing immune-surveillance of tumor development .
TGF-beta-2 (transforming growth factor-beta-2, TGFB2, G-TsF, Glioblastoma-derived T-cell suppressor factor.