The dense functional groups terminated on surface of dendrimers can react with intrinsic functional groups in protein-based scaffolds to form covalent binding. Conveniently in this way, scaffold stability can also be tailored by controlling the extent of cross-linking, which has the benefit of extending their in vivo life . Availability of multiple functional groups effectively amplifies the number of sites available for conjugation with exogenous bioactive molecules. For example, Chan et al.  used generation 1 polyamidoamine (G1 PAMAM) dendrimer.
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