What does fak stand for?
fak stands for focal adhesion kinase p125
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Samples in periodicals archive:
Melanocyte migration is an important event in re-pigmentation of vitiligo. We have demonstrated that narrow-band ultraviolet B (UVB) irradiation stimulated cultured keratinocytes to release a significant amount of basic fibroblast growth factor (bFGF). Furthermore, narrow-band UVB enhanced migration of melanocytes via increased expression of phosphorylated focal adhesion kinase (p125.
Zachary I, Rozengurt E (December 1992). "Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes". Cell 71 (6): 891–4. doi:10. 1016/0092-8674(92)90385-P. PMID 1458538.
As outlined by Brabek et al. , the architecture and composition of the microenvironment in terms of structural and biochemical properties of the ECM (fiber network morphology collagen content, fiber thickness, extent of intrafibrillar cross-links, and the ratio mesh size-diameter of the migrating cell) determines the degree of resistance the moving cell encounters. This in turn will determine the migration strategy and efficiency of cancer cell invasion. Tumor cells are capable of mechanosensing the composition of the ECM which is facilitated by integrin-mediated adhesions and downstream mechanosensor proteins such as focal adhesion kinase (p125.