What does EP stand for?
EP stands for endocochlear potential
This definition appears rarely
See other definitions of EP
Samples in periodicals archive:
But lidocaine had serious side effects, and its impact on tinnitus only lasted for a half hour or so, Vernon says. Paul Guth, a pharmacologist who researches hearing and balance mechanisms at the Tulane Medical School, New Orleans, says side effects of lidocaine in tests to treat tinnitus included amnesia, slurred speech, and fainting. Guth's research has been into medications that target the hearing system. One such drug, aminooxyacetic acid (AOAA), had reached clinical trials in controlling epileptic seizures and seemed to be safe in humans. A former student, Richard Bobbin, reported to Guth he found AOAA also had a measurable effect on endocochlear potential.
Using mouse models, it has been shown that pendrin is required between embryonic day 16. 5 and postnatal day two for normal hearing. Pendrin is not required for maintenance of hearing [Choi et al 2011a]. Extensive studies in mouse mutants segregating a targeted deletion of Slc26a4 have also shown that endolymph volume in the homozygous null mice (Slc26a4-/-) is increased and tissue mass in areas occupied by type I and II fibrocytes is reduced. Slc26a4-/- mice lack an endocochlear potential.