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Vindesine (Systemic) USAN: Vindesine VA CLASSIFICATION Primary: AN900 Commonly used brand name(s): Eldisine®. Other commonly used names are desacetyl vinblastine amide sulfate and vincaleukoblastine. Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s). *Not commercially available in the U. S.
Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on microtubules in vitro. Himes RH, Kersey RN, Heller-Bettinger I, Samson FE.
THE EFFICACY OF DESACETYL VINBLASTINE AMIDE (DVA) was tested against five human sarcomas hetero-transplanted into nude mice. Marked antitumor effect was found against a lipoblastic liposarcoma, including complete regressions of tumor in some animals. A lesser, though statistically significant, antitumor effect was observed with a malignant schwannoma. No antitumor activity was seen against a leiomyosarcoma, epithelioid sarcoma, or Ewing's sarcoma.
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5 µm). At 10 µm, the three alkaloids also interact with preformed microtubules in vitro, causing spiral-like distortions of the microtubules. No effect of the alkaloids on polymerization of another fibrous protein, actin, was observed. Thus the differential actions of vinblastine, vincristine, and desacetyl vinblastine amide.
Jumean, H. G. , Camitta, B. , Holcenberg, J. and Hodach, A. (1979), Desacetyl vinblastine amide sulfate induced ineffective erythropoiesis. Cancer, 44: 64–68. doi: 10. 1002/1097-0142(197907)44:1<64::AID-CNCR2820440112>3. 0.
DESACETYL VINBLASTINE AMIDE SULFATE? INDUCED INEFFECTIVE ERYTHROPOIESIS HANI G. JUMEAN, MD,* BRUCE CAMITTA, AND ALBERTINA MD, JOHN HOLCENBERG, HODACH, PHD MD, Ineffective erythropoiesis occurred during desacetyl vinblastine amide sulfate (VDS) therapy of a patient with metastatic Ewing's sarcoma. The peripheral blood was characterized by anisocytosis, poikilocytosis and reticulocytopenia. Bone marrow showed megaloblastic red cell hyperplasia with nuclear frag- mentation, binuclearity and abnormal metaphases.