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The 1,634 study participants had their symptoms recorded on questionnaires completed by physicians, designed to determine the effect of Agnus castus on psychological and physical symptoms and the four classic symptom complexes, defined as depression, anxiety, craving and hyperhydration (DACH). Improvement was assessed according to the standard Clinical Global Impression Scale, which allows patients to rate symptomatic change on a scale of one to seven (very much improved to very much worse).