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The Friedewald formula (FF) is useful for calculating serum low-density lipoprotein cholesterol (LDL-C) values, but has a remarkable deviation and limitation especially in hypertriglyceridemia. We modify the formula which is now more suitable for LDL-C calculation.
Low-density lipoprotein cholesterol (LDL-C) Unit Conversion between mg/dL and mmol/L
We used inverse variance weighted meta-regression analysis to investigate the association between differences in the change in high density lipoprotein cholesterol and low density lipoprotein cholesterol concentrations between treatment and control groups and the risk ratios of clinical outcomes of interest. 33 34 To take into account non-lipid effects of specific drugs (such as potential pro-thrombotic effects of hormone therapy), we included a categorical variable of drug class in the meta-regression model and did a meta-regression analysis stratified by drug class.