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Biological Activity A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein.
Zhang YH, et al. (1997). "Kinase suppressor of Ras is ceramide-activated protein kinase". Cell 89 (1): 63–72. doi:10. 1016/S0092-8674(00)80183-X. PMID 9094715.
"Phosphorylation of Raf by ceramide-activated protein kinase. "Yao B. , Zhang Y. , Delikat S. , Mathias S. , Basu S.
181 TNF-R2 can also induce JNK, but not ERKs. 182 A protein containing a domain with low DD homology termed MADD or Rab3-GAP binds to the DD of TNF-R1 and is able to activate MAP kinase pathways. 183,184 Various splice variants of MADD exist which are also termed DENN. 185 Further, the adapter protein Grb2 binds to a PLAP motif of TNF-R1, thereby potentially linking this receptor via SOS to Ras, c-Raf and the ERKs. 186 This signal, however, appears not sufficient to efficiently activate the MAP kinases, as FAN/nSMase-derived ceramide acting on the ceramide-activated protein.