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Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens. Xu Q1, Liu G, Yuan X, Xu M, Wang H, Ji J, Konda B, Black KL, Yu JS.
Antigen: neuromuscular junction and reactive Schwann cell associated antigen.
28, 29 In contrast to DCs, the processing pathways within Mφ are apparently geared towards antigen degradation, which would explain why DCs are more efficient at cross-presentation. 30, 31 However, such observations are based on studies carried out using bone marrow-derived Mφ (BM-Mφ) with little or no data examining other types of Mφ, especially Sp-Mφ. Furthermore, hardly any studies have assessed the role of cell differentiation on MHC-I-restricted antigen presentation in Mφ. In this report, we analyzed the differentiation of Sp-Mφ in relation to antigen presentation and illustrate for the first time that Sp-Mφ are extremely efficient in cross-presenting cell-associated antigens.
You are going to email the following Plasma cells in multiple myeloma express a natural killer cell- associated antigen.
In the case of class I presentation it has been shown that, at least in vitro, exogenous nonreplicating antigens fail to sensitize targets for CTL recognition (6). In contrast, direct introduction of the same proteins into the cell cytoplasm results in effectiveCTL lysis (7, 8). Despite these in vitro studies, there is some evidence to suggest that in vivo, exogenous antigens may be processed for class I-restricted T lymphocyte recognition. For example, it has been shown that in MHC heterozygous Fl mice, CTL restricted to one parental MHC-encoded product can be primed against foreign minor histocompatibility antigens or viral antigens by introducing the antigens on cells expressing the MHC ofthe other parent (9, 10). Consequently, these cell-associated antigens.