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We are also very interested in neurodegenerative processes such as Alzheimer's disease. We have been studying the role of the calcium-binding protein calbindin D28K in suppressing the onset of Alzheimer's. Calbindin D28K appears to regulate both the amyloid and neurofibrillary tangle pathologies that define the disease.
Mattson MP, Rychlik B, Chu C, Christakos S: Evidence for calcium-reducing and excito-protective roles for the calcium-binding protein calbindin-D28k in cultured hippocampal neurons. Neuron 1991, 6(1):41-51. PubMed Abstract | Publisher Full Text.
Most interneuron types have also been characterised by their neurochemical features. Renshaw cells, for example, express not only glycine, their characteristic inhibitory neurotransmitter, but they reportedly synthesize calcium binding proteins calbindin-D28k.