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InhA (EC 1. 3. 1. 9, enoyl-[acyl-carrier-protein] reductase), involved in mycolic acid synthesis, is a target for front-line anti-tubercular drugs, such as isoniazid and ethionamide . Enzymes needed for biosynthesis of mycolic acids, such as methyl transferase (PcaA), beta-ketoacyl-acyl carrier protein synthase.
Choi KH, Kremer L, Besra GS, Rock CO: Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J Biol Chem 2000, 275(36):28201-7. PubMed Abstract | Publisher Full Text.
Garwin JL, Klages AL, Cronan JE Jr: Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis. J Biol Chem 1980, 255:3263-3265. PubMed Abstract | Publisher Full Text.
The fatty acid synthase-I and fatty acid synthase-II pathways producing mycolic acids are linked by the beta-ketoacyl-(acyl-carrier-protein) synthase III enzyme, often designated as mtFabH. Novel inhibitors of this enzyme could potentially be used as therapeutic agents.