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Benzene oxide, the benzoquinones, muconaldehydes, and benzene diol epoxides (formed from CYP oxidation of benzene dihydrodiol) are electrophiles that readily react with peptides and proteins (Bechtold et al. 1992; Henderson et al. 2005; McDonald et al. 1993; Waidyanatha et al. 2005) and can thereby interfere with cellular function (Smith 1996). Reactions between 1,4-benzoquinone and critical nucleophilic loci in topoisomerase II, an important enzyme involved in DNA replication and maintenance, are mentioned as likely key events in the cascade of effects related to benzene’s ability to damage chromosomes (Chen and Eastmond 1995; Lindsey et al.