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What does IAA stand for?

IAA stands for anti-insulin autoantibodies


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? Such patients with elevated titers of anti-insulin autoantibodies frequently present with hypoglycemia. ? The disease in Japan is essentially confined to DR4-positive individuals with DRB1*0406239. ? Even a Portuguese patient with the syndrome had DRB1*0406316. ? In Hirata syndrome the anti-insulin autoantibodies are polyclonal. ? Some patients have monoclonal anti-insulin autoantibodies that also induce hypoglycemia and for these patients there is not an HLA association316.
Since we first applied PEG precipitation method, which had been used to detect anti-insulin autoantibodies, to diagnose macroprolactinemia due to anti-PRL autoantibodies [5], this method has been used for the screening of macroprolactinemia because of its simplicity [19–28]. The method was validated against gel filtration chromatography, a gold standard for the diagnosis of macroprolactinemia [19].
Markers of the immune destruction of the β-cell include islet cell autoantibodies, autoantibodies to insulin, autoantibodies to GAD (GAD65), and autoantibodies to the tyrosine phosphatases IA-2 and IA-2β. One and usually more of these autoantibodies are present in 85–90% of individuals when fasting hyperglycemia is initially detected. Also, the disease has strong HLA associations, with linkage to the DQA and DQB genes, and it is influenced by the DRB genes.