What does ACT stand for?
ACT stands for acinar cell tumor
This definition appears rarely
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Table of contents General: primary references normal pancreas exocrine pancreas endocrine pancreas embryology cytology minor abnormalities Congenital anomalies: agenesis annular pancreas familial fibrocystic pancreatic atrophy heterotopic pancreas nesidioblastosis pancreas divisum Pancreatitis: acute autoimmune chronic CMV eosinophilic graft versus host disease herpes simplex Diabetes mellitis: general IDDM/type 1 NIDDM/type 2 maturity onset diabetes complications Cysts: true cysts cystic fibrosis lymphoepithelial cysts mucinous non-neoplastic cysts pseudocysts WHO classification of tumors: general Acinar cell tumors.
MCF-10A cells are near diploid and normal human mammary epithelial cells. In three-dimensional reconstituted basement membrane culture, they undergo a well-defined program of proliferation, differentiation, and growth arrest, forming acinar structures that recapitulate many aspects of mammary architecture in vivo. The pre-malignant MCF-10AT cells and malignant MCF-10CA1a lines were sequentially derived from the MCF-10A parental cell line first by expression of a constitutively active T24 H-Ras generating the MCF-10AT cell line. This was followed by repeated selection for increasingly aggressive tumor formation from cells recovered from xenograft tumors in immuno-compromised mice, generating the MCF-10CA1a cell line. When inoculated subcutaneously into the flanks of immuno-compromised mice, MCF-10AT cells occasionally form tumors, whereas MCF-10CA1a cells invariably form tumors with a shorter latency than MCF-10AT derived tumors.