This definition appears rarely
Aquaporin 6 (AQP6) is expressed in the acid-secreting intercalated cells of the collecting ducts in the kidney. It co-localizes with H+ ATPase, suggesting that low pH could activate the protein. Intracellular vesicles in the α-intercalated cells are thought to permit renal acid secretion by generating hydrochloric acid. To maintain electroneutrality, a pathway for anion secretion must exist and ClC-5 is located at this site.